Welcome to the website for the Rembrandt Study. This is a multisite study with locations in Pittsburgh, Nashville, and Chicago looking to better understand recurrent depression in older adults.

Why this study?

Depression is a recurrent illness and even with successful antidepressant treatment, older adults with late-life depression are at high risk of recurrence.  However, neurobiological processes that contribute to vulnerability to recurrence are poorly understood, limiting our ability to target mechanisms in prevention studies.  The current study will elucidate neurobiological contributors to recurrence, examine the interrelationship between recurrence and cognitive decline, and provide data on the predictive utility of clinical monitoring in older adults. Click here to learn more about the study.